Signaling and Apoptosis in Influenza Virus-Infected Cells
from: Influenza Virology: Current Topics (Edited by: Yoshihiro Kawaoka). Caister Academic Press, U.K. (2006)
Infection of cells with viruses commonly leads to the activation of a variety of different signaling pathways within the infected cells. It is quite obvious that DNA viruses or retroviruses with DNA intermediates in their replication cycle need these signaling processes to activate the cellular DNA and protein synthesis machinery. However, it is not so clear how RNA viruses, such as influenza viruses cope with intracellular signaling. Since intracellular signaling pathways represent key switches in the determination of cell fate, the knowledge about their activation and function in infected cells may help to unravel some of the secrets of virus-host cell interactions. In this overview we will focus on recent advances on the function of intracellular signaling pathways and the induction of the apoptotic program in influenza virus infected cells. The role of these signaling events in the constant struggle between efficient virus propagation and the innate antiviral defense will be discussed read more ...