Antibody Therapeutics Against Flaviviruses
Michael S. Diamond, Theodore C. Pierson, and John T. Roehrig
from: Molecular Virology and Control of Flaviviruses (Edited by: Pei-Yong Shi). Caister Academic Press, U.K. (2012)
Flaviviruses are a group of small RNA enveloped viruses that cause severe disease in humans worldwide. Recent advances in the structural biology of the flavivirus envelope proteins and virion have catalyzed rapid progress toward understanding how the most potently inhibitory antibodies neutralize infection. These insights have identified factors that modulate the potency of neutralizing antibodies and provided insight into the design of novel antibody-based therapeutics against several members of the flavivirus genus. This chapter will discuss recent advances in the understanding of the mechanisms of antibody neutralization of flaviviruses, and review the progress towards development of antibody-based therapeutics against several different flaviviruses of global concern read more ...