Ingenious Genes: The Diverse Roles of Long Noncoding RNA in Regulatory Processes
Emily M. Darrow and Brian P. Chadwick
from: Epigenetics: Current Research and Emerging Trends (Edited by: Brian P. Chadwick). Caister Academic Press, U.K. (2015) Pages: 185-198.
Abstract
The general principles of the Central Dogma describe the flow of genetic information from the transcription of DNA into RNA that is subsequently translated into protein. While there has long been an appreciation for those transcriptional units that do not complete this course and function at the level of RNA, the breadth and extent of molecules that fall into this category is undoubtedly far greater than could have been imagined in the early 1990's when the first long noncoding RNAs (lncRNA) were discovered. Experimental evidence firmly associates lncRNAs with epigenetic regulation of gene expression. In this chapter, we provide a broad overview of the many types and functions of lncRNA and briefly cover the various ways in which these RNA molecules impact and regulate protein-coding genes that do conform to the Central Dogma read more ...
