The Multifaceted Roles of YY1 in the Establishment of the Cellular Epigenetic Landscape
Raed Rizkallah
from: Epigenetics: Current Research and Emerging Trends (Edited by: Brian P. Chadwick). Caister Academic Press, U.K. (2015) Pages: 1-22.
Abstract
Yin Yang 1 (YY1) is an essential multifunctional protein needed for the regulation of a very wide spectrum of biological processes. Since its initial identification as a transcription factor that can repress, activate, or initiate transcription, YY1 has been shown to regulate hundreds of mammalian genes. Our knowledge of the mechanisms governing epigenetic regulation has grown exponentially over the past two decades. Mounting evidence in the scientific literature clearly indicates that YY1 is a central player in the establishment of the cellular epigenetic landscape. This chapter will focus on the multilayered roles of YY1 in epigenetic regulation with emphasis on the polycomb pathway, genomic imprinting, and X-chromosome inactivation. In addition, the known mechanisms of YY1 regulation will be discussed, along with possible implications on human health and disease through epigenetic disturbance read more ...
