Enterovirus Control of Cytoplasmic RNA Granules
Richard E. Lloyd
from: Enteroviruses: Omics, Molecular Biology, and Control (Edited by: William T. Jackson and Carolyn B. Coyne). Caister Academic Press, U.K. (2018) Pages: 93-112.
Abstract
RNA granules are dynamic structures in cells that are closely linked to repression of gene expression and comprise essential parts of the life cycle of mRNPs. The two general types of RNA granules in somatic cells are stress granules (SGs) and processing bodies (P-bodies, PBs), both of which are manipulated by many types of viruses. Enteroviruses such as poliovirus (PV) and coxsackievirus B3 (CVB3) induce stress granule formation but almost immediately block their formation during the course of infection. PBs are constitutively present, and Enterovirus infection results in their complete dispersal. This review discusses these processes and the current understanding of the underlying mechanisms. In addition, the review discusses reasons viruses control RNA granules, including accumulating data suggesting linkage between RNA granule formation and innate immune sensing and activation read more ...
