The Heat Stable and Heat Labile Enterotoxins Produced by ETEC
Sascha Kopic, Ahmad Saleh and John P. Geibel
from: Pathogenic Escherichia coli: Molecular and Cellular Microbiology (Edited by: Stefano Morabito). Caister Academic Press, U.K. (2014)
Enterotoxigenic E. coli (ETEC) produces two toxins: a heat-stable and a heat-labile enterotoxin. Both toxins differ strongly in their structure, their respective receptors and their intracellular mode of action. However, they target common molecular endpoints on the apical membrane of the enterocyte, leading to a intestinal hypersecretion of chloride and a concomitant inhibition of sodium absorption. This chapter will review toxin structure, their receptors and the intracellular processing and signaling involved in toxin exposure. Furthermore, basic principles of intestinal water and ion homeostasis are discussed read more ...