The Role of Noncoding RNAs in EBV-induced Cell Growth and Transformation
from: Epstein-Barr Virus: Latency and Transformation (Edited by: Erle S. Robertson). Caister Academic Press, U.K. (2010)
Epstein-Barr virus (EBV) expresses two small RNAs known as EBERs (EBV-encoded RNAs) and several microRNAs. EBERs are the most abundant viral transcript produced during latent infection by EBV in a wide variety of cell types and disease conditions. They have been demonstrated to have a variety of effects on cell growth and physiology in experiments performed in vitro and in cell culture remains to be defined. Although the abundance of EBERs in latently infected cells implies an important function, their biological role in vivo and their molecular mechanisms of action remain poorly understood. The current state of knowledge with respect to the regulation of EBER expression, their structure, their interactions with cellular proteins and their roles in protecting EBV mediated cell transformation is presented and the controversies regarding EBER functions are discussed. EBV microRNAs function in regulating both EBV genes and cellular genes. Expression of EBV miRNAs is dependent on a variety of factors, including the host cell type. The potential roles of EBV miRNAs in oncogenesis, immune mechanisms and gene regulation are presented read more ...