Regulation of EBV Latency by LMP2A
Kathryn T. Bieging, Leah J. Anderson, and Richard Longnecker
from: Epstein-Barr Virus: Latency and Transformation (Edited by: Erle S. Robertson). Caister Academic Press, U.K. (2010)
Latent membrane protein 2A (LMP2A) is expressed in cells latently infected with EBV, as well as in many of the pathologies that are associated with EBV infection. The consistent detection of LMP2A in various EBV-associated malignancies and latency programs point to the essential role that this protein plays both in the viral life cycle and in disease manifestations. Detailed analysis of LMP2A function has uncovered dramatic effects on B cell biology. LMP2A has been described as a B cell receptor (BCR) signaling mimic, inducing signaling cascades that inhibit apoptosis and promote cell survival. LMP2A also has dramatic effects on development and differentiation as evidenced by transgenic mouse phenotypes and analysis of transcriptional profiles. The molecular bases for these functions of LMP2A underlie its contribution to development of various epithelial and lymphoid malignancies including nasopharyngeal carcinoma and Hodgkin's Lymphoma, and help to explain the role of LMP2A in the EBV life cycle and maintenance of viral latency read more ...