DNA Tumour Viruses and the Host DNA Damage Response
Amy Hafez and Micah Luftig
from: DNA Tumour Viruses: Virology, Pathogenesis and Vaccines (Edited by: Sally Roberts). Caister Academic Press, U.K. (2018) Pages: 215-230.
When viruses infect human cells, they must successfully resist host defences to faithfully replicate their genetic material. To do so, viruses interface with a number of cellular processes including the host DNA damage response. DNA viruses have a particularly precarious situation, in that they must infect cells without alerting the host DNA damage response pathway to recognize and launch a response against the viral DNA genome. This challenge has required DNA viruses to develop unique methods to allow the virus to interact with and evade the host DNA damage response. In this chapter, we focus on four DNA tumour viruses, Epstein-Barr virus (EBV), Kaposi sarcoma virus (KSHV), human papillomavirus (HPV), and adenovirus. These viruses modulate the DNA damage response by activating or deactivating sensors of DNA damage as well as key downstream effector molecules. Here we review the current literature discussing the integrated relationship between DNA tumour viruses and the host DNA damage response during lytic and latent viral infection read more ...