Molecular Pathogenesis of Kaposi Sarcoma Herpes Virus-Associated Cancers
Silvia Gramolelli, Giuseppe Balistreri and Päivi M. Ojala
from: DNA Tumour Viruses: Virology, Pathogenesis and Vaccines (Edited by: Sally Roberts). Caister Academic Press, U.K. (2018) Pages: 179-200.
Kaposi sarcoma herpesvirus (KSHV) is the causative agent of three malignancies, namely Kaposi sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castelman disease (MCD) and it is also the etiological agent of an inflammatory cytokine syndrome, KICS. In order to ensure its own survival and the successful accomplishment of its two modes of life cycle, a latent and a lytic phase, KSHV subverts several cellular processes. This chapter focuses on virus-host interactions that include manipulation of the cell cycle and apoptotic cascade, atypical differentiation of infected cells, aberrant angiogenesis and KSHV-induced metabolic alterations. By deregulating these cellular events, KSHV modulates the infected cell microenviroment and promotes viral tumourigenesis. Lastly, we present an overview of the current therapies for KSHV-associated malignancies and provide examples of how the study of KSHV molecular pathology could pave the way for new therapeutic approaches read more ...