Induction of Genomic Instability by Human Papillomavirus Oncoproteins
Karl Münger and Stefan Duensing
from: Small DNA Tumour Viruses (Edited by: Kevin Gaston). Caister Academic Press, U.K. (2012)
The high-risk human papillomavirus (HPV)-encoded oncoproteins E6 and E7 have been instrumental to dissect crucial pathways of genomic instability and carcinogenic progression. This includes the notion that cell cycle deregulation and the development of numerical and structural chromosomal instability are intricately linked. The HPV E6 and E7 oncoproteins disrupt p53 and pRB signaling, respectively, and it has become evident that these events set the stage for numerous host cellular aberrations that can promote genomic instability and thus ultimately promote malignant progression. Many if not all of these host cellular aberrations can also be detected in non-virus-associated tumours, making HPV-associated carcinogenesis an attractive model system to analyze the molecular mechanisms and functional consequences of genomic instability in cancer in general read more ...