Caister Academic Press

Evolutionary Dynamics of Dengue Virus

Shannon N. Bennett
from: Frontiers in Dengue Virus Research (Edited by: Kathryn A. Hanley and Scott C. Weaver). Caister Academic Press, U.K. (2010)

Abstract

This chapter addresses the following topics with respect to the evolutionary dynamics of dengue viruses in humans. Beginning with an introduction to evolutionary thinking and terminology, particularly with relevance to RNA viruses, the macroevolutionary divergence from dengue progenitors into the 4 serotypes is discussed. The microevolutionary dynamics within dengue serotypes and the forces of evolution-mutation, migration, recombination, selection and drift-that drive them are outlined. Finally, I summarize frontiers in understanding the evolutionary ecology of dengue, epitomized by the study of phylodynamics, in which interactions amongst host, vector and virus population sizes, their dynamic distributions, immune landscapes and evolutionary dynamics are modeled read more ...
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