Caister Academic Press

Host and Virus Determinants of Susceptibility and Dengue Disease Severity

Maria G. Guzman, Beatriz Sierra, Gustavo Kouri, Jeremy Farrar, and Cameron Simmons
from: Frontiers in Dengue Virus Research (Edited by: Kathryn A. Hanley and Scott C. Weaver). Caister Academic Press, U.K. (2010)


The pathogenesis of dengue infection is complicated and, despite intensive research, not well understood. Here, we review the burden of disease and the host (age, ethnicity, co-morbidities, immune and genetic factors) and viral (epidemiological and genetic factors) determinants for disease severity. This review is informed both by current knowledge of the topics and our specific experiences accumulated from Cuba and Vietnam read more ...
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