Translation and Processing of the Dengue Virus Polyprotein
R. Padmanabhan and Alex Y. Strongin
from: Frontiers in Dengue Virus Research (Edited by: Kathryn A. Hanley and Scott C. Weaver). Caister Academic Press, U.K. (2010)
Positive strand RNA viruses, including flaviviruses, generally utilize the translational machinery of the host to synthesize viral proteins either in a cap-dependent or cap-independent manner to produce polyprotein precursors which are then processed into mature proteins. Polyprotein processing is accomplished by the concerted action of host and viral proteases. While some viruses, such as the hepatitis C virus code for more than one protease to perform distinct functions, flaviviruses code for a novel two-component serine protease which participates in early and late stages of the viral life cycle. This chapter summarizes the state of knowledge of polyprotein processing by the viral protease since its discovery approximately 20 years ago read more ...