Corynebacterium glutamicum as a Platform Organism for the Secretory Production of Heterologous Proteins
from: Corynebacterium glutamicum: From Systems Biology to Biotechnological Applications (Edited by: Andreas Burkovski). Caister Academic Press, U.K. (2015) Pages: 161-178.
Corynebacterium glutamicum is widely used as an industrial workhorse for the production of amino acids and other low molecular weight compounds. However, an increasing amount of evidence indicates that this microorganism likewise might possess a great potential as an alternative platform organism for the secretory production of heterologous proteins. Besides giving an overview on the major protein secretion routes present in C. glutamicum, i.e. the general secretion (Sec) system and the twin-arginine translocation (Tat) system, this review summarizes the attempts that have been made so far to use C. glutamicum as a host system for the expression and subsequent secretion of foreign proteins. In addition, this review also addresses recent progress with respect to producer strain improvement and process optimization read more ...