Caister Academic Press

Human Coronavirus NL63, a Long Lost Brother

Krzysztof Pyrc and Lia van der Hoek
from: Coronaviruses: Molecular and Cellular Biology (Edited by: Volker Thiel). Caister Academic Press, U.K. (2007)


Over the last decade a number of novel human respiratory viruses have emerged or have been recognized. A novel group I coronavirus, human coronavirus NL63 (HCoV-NL63) was identified in 2004 in the Netherlands in children and adults with acute respiratory illness. Worldwide analysis of clinical specimen indicated that this virus has widely spread within the human population. It is observed mostly in young children, elderly people and immunocompromised patients with upper and lower acute respiratory tract disease (1-10% of all respiratory infections). This chapter will discuss current knowledge on HCoV-NL63 replication, pathogenesis, disease burden and advances in treatment strategies read more ...
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