SARS-Coronavirus and the Antiviral Cytokine Response
Martin Spiegel and Friedemann Weber
from: Coronaviruses: Molecular and Cellular Biology (Edited by: Volker Thiel). Caister Academic Press, U.K. (2007)
Intracellular pathogens such as SARS-Coronavirus (SARS-CoV) have to cope intensively with the innate immune system. Type I interferons (IFN-a/b) represent an important part of this host defense. IFNs are potent, antivirally active cytokines which can be produced by all nucleated cells in response to infection. Moreover, professional IFN producer cells such as dendritic cells are able to secrete immense amounts of IFNs within short time. IFNs trigger the synthesis of antivirally active proteins and shape adaptive immunity. Thus, in order to establish infection, viruses were forced to evolve efficient anti-IFN strategies. There is growing evidence that SARS-CoV is no exception to that rule. Here, we attempt to summarize the current state of knowledge regarding the interaction SARS-CoV with components of the IFN system, its connection to the induction of other cytokines, and the consequences for the pathogenesis of SARS read more ...