Caister Academic Press

SARS Coronavirus - Pathogenesis and Correlation With Clinical Disease

John M. Nicholls and Joseph S.M. Peiris
from: Coronaviruses: Molecular and Cellular Biology (Edited by: Volker Thiel). Caister Academic Press, U.K. (2007)

Abstract

Human infection by SARS coronavirus appears to be limited to the respiratory tract where infection of susceptible cells leads to damage to the pneumocytes resulting in a histological picture of diffuse alveolar damage and a clinical picture of adult respiratory distress syndrome. Diarrhoea is also present but there is limited evidence of damage to the intestinal epithelium. The damage to the respiratory tree appears limited to the lower respiratory tract and there is evidence that the immune response plays a part in the outcome of patients with SARS read more ...
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