Feline Coronaviruses: A Tale of Two-Faced Types
Bert Jan Haijema, Peter J.M. Rottier, and Raoul J. de Groot
from: Coronaviruses: Molecular and Cellular Biology (Edited by: Volker Thiel). Caister Academic Press, U.K. (2007)
Feline coronaviruses (FCoVs) are common pathogens of cats. Two serotypes (I and II) have been recognized and, to add further spice, each serotype occurs in two markedly different pathotypes. The most common pathotype, enteric FCoV (eFCoV) causes a mild, often unapparent enteritis, the other one, feline infectious peritonitis virus (FIPV), a devastating, highly lethal systemic infection. During the last ten years, our knowledge of the pathogenesis of feline infectious peritonitis (FIP) and of the relationships between the different FCoV sero- and pathotypes has increased considerably. In this Chapter, we will focus on (i) the pathogenesis and natural history of FCoV infections, (ii) the molecular biology and molecular genetics of FCoVs, and (iii) the development of new and effective vaccines read more ...