Regulation of HCMV Gene Expression by Chromatin Remodelling
Mark Bain, Matthew Reeves and John Sinclair
from: Cytomegaloviruses: Molecular Biology and Immunology (Edited by: Matthias J. Reddehase). Caister Academic Press, U.K. (2006)
Abstract
Although the myeloid lineage is important for the carriage of latent HCMV genomes, the mechanisms underlying how the latent state is maintained and how latent virus reactivates, are unclear. In this review we discuss how initial findings using model cell lines, mobility shift assays and transient transfection experiments, together with more recent developments such as chromatin immuno-precipitation assays, have led to an understanding that the higher-order chromatin structure around the viral major immediate-early promoter region, has profound effects on the control of viral latency and reactivation read more ...
