Interactions of the Chlamydial Inclusion with the Host Cell
Christine Sütterlin and Isabelle Derré
from: Chlamydia Biology: From Genome to Disease (Edited by: Ming Tan, Johannes H. Hegemann and Christine Sütterlin). Caister Academic Press, U.K. (2020) Pages: 111-134.
Bacteria of the Chlamydia genus are obligate intracellular pathogens that reside at all times within a membrane-bound cytoplasmic compartment called the chlamydial inclusion. This replicative niche is necessary for the chlamydial developmental cycle and depends on many interactions with the host cell. In this chapter, we will discuss how these bacteria orchestrate the intricate relationship of the inclusion with most of the cellular elements of their host cell. In the first section, we will focus on the cytoskeleton and summarize our knowledge on how and why the infection alters F-actin, intermediate filaments and microtubules. We will also discuss the interaction of the inclusion with the centrosome, including its potentially negative consequences for the host cell. In the second section, we will describe how interactions between the inclusion and the endoplasmic reticulum, the Golgi and mitochondria are established, and how they promote the infection. In the last section, we will focus on associations of the inclusion with lipid droplets and peroxisomes, which have both been found to translocate into the inclusion. Overall, this description shows that chlamydiae are master manipulators of their host cell read more ...