Alternative Infection Models for Campylobacter jejuni
Nicola J. Senior, Sok Kiang Lau, Roberto M. La Ragione and Olivia L. Champion
from: Campylobacter Ecology and Evolution (Edited by: Samuel K. Sheppard). Caister Academic Press, U.K. (2014)
Abstract
Research using experimental hosts enables the lifecycle, metabolism and virulence mechanisms of Campylobacter jejuni to be interpreted in a contextual manner. However, the ability of C. jejuni to cause disease appears to be dependent not only on the bacterial strain but also on the host; C. jejuni is able to cause disease in certain hosts yet it remains avirulent in other host species. Mammalian models of infection are the most widely used and best characterised models of human disease, yet there are ethical, social and scientific limitations of these models. These concerns have driven work to reduce, refine and replace mammalian models of infection and this chapter considers the use of alternative infection models for C. jejuni research. This chapter ends with a review of the metabolism of C. jejuni in the context of host adaptation read more ...
