Genetic Mechanisms Involved in Campylobacter jejuni Survival Under Oxidative Stress Conditions
Ozan Gundogdu, Brendan W. Wren and Nick Dorrell
from: Campylobacter Ecology and Evolution (Edited by: Samuel K. Sheppard). Caister Academic Press, U.K. (2014)
Abstract
Campylobacter jejuni is the major cause of human bacterial gastroenteritis. As a microaerophilic bacterium, C. jejuni will be exposed to reactive oxygen species (ROS) during the course of normal bacterial metabolism as well as during colonisation or infection, from the host immune system. C. jejuni contains a number of different mechanisms for countering the effects of oxidative stress and the control of the C. jejuni oxidative stress response is complex involving multiple inter-linked levels of regulation, with two new regulators of the oxidative stress response recently identified. In this chapter, we cover both the mechanisms of C. jejuni oxidative stress defence and the current understanding of the increasingly complex regulation of this oxidative stress response read more ...
