Bacterial Biofilms and Host Immune Response
Pradeep Kumar Singh, Vivek Kumar Yadav, Deepmala Sharma, Vishnu Agarwal and Vandan Nagar
from: Microbial Biofilms: Current Research and Practical Implications (Edited by: Arindam Mitra). Caister Academic Press, U.K. (2020) Pages: 195-216.
Abstract
The biofilm includes a group of microbial cells which stick together and remain attached to a surface. Biofilm-associated microbial cells secrete extra-cellular polymeric substances and are embedded in this slimy matrix. Components of the extracellular polymeric substance have a specific role in the development of biofilm. Biofilms are the product of the microbial developmental process which involves different stages, including initial attachment, irreversible attachment, maturation, and dispersion. In many cases, the biofilm mode of microbial growth contributes to antibiotic resistance and escape from the host immune system. Device-associated microbial colonisation plays a vital role in the biofilm-related infections, and a large amount of money is being used for the eradication of microbial growth from these devices. Biofilm interacts with the different components of the host immune system and may contribute to the stimulation or suppression of immune response. Different immune cells, including neutrophils, macrophages, T Cells, and B-cells, generate a specific response against biofilms read more ...
