Novel Insights into Polycyclic Aromatic Hydrocarbon Biodegradation Pathways Using Systems Biology and Bioinformatics
Ohgew Kweon, Seong-Jae Kim, John B. Sutherland and Carl E. Cerniglia
from: Microbial Biodegradation: From Omics to Function and Application (Edited by: Jerzy Długoński). Caister Academic Press, U.K. (2016) Pages: 143-166.
Biodegradation of polycyclic aromatic hydrocarbons (PAHs entails a complex and diverse set of biological reactions. Although there has been a massive effort over the years, understanding of the mechanism of PAH biodegradation has been limited when using the traditional approaches of genetics and biochemistry. The application of systems biology approaches, with advanced high-throughput analytical technologies, provides new global insights into not only the direct molecular mechanisms but also the genome-wide cellular ecophysiological responses involved in PAH degradation. This review describes research accomplishments from earlier traditional genetic and biochemical studies as well as the recent achievements of a combination of genomic, proteomic, and bioinformatics approaches to elucidate pathways for the degradation of high-molecular-weight (HMW) PAHs read more ...