Lipidomics in Studies on Adaptation Mechanisms of Microorganisms to the Toxic Effects of Hazardous Compounds
Przemysław Bernat
from: Microbial Biodegradation: From Omics to Function and Application (Edited by: Jerzy Długoński). Caister Academic Press, U.K. (2016) Pages: 85-98.
Abstract
Anomalies in environmental conditions activate a series of processes in microbial cells that allow them to minimise the negative impact of the environmental stress. These environmental factors, such as temperature, nutrient shortage, or dangerous pollutants, may result in changes in the cytoplasmic membrane. Since membranes constitute the main target for the action of toxic compounds, most adaptive mechanisms are concerned with maintenance of the membrane fluidity and lipid-phase stability. These processes can be modulated by altering the lipid composition of the membrane. In order to understand the contribution of membrane lipid composition to the functionality of membranes, comprehensive structural and quantitative information on the organellar lipidomics is essential. Improved lipidomic technologies, which are described in this review, have greatly enhanced our knowledge about the lipid biology of microorganisms at the level of individual species read more ...
