The Secreted Proteins of Pseudomonas aeruginosa: Their Export Machineries, and How They Contribute to Pathogenesis
Kim R Hardie, Stephanie Pommier and Susanne Wilhelm
from: Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis (Edited by: Karl Wooldridge). Caister Academic Press, U.K. (2009)
Pseudomonas aeruginosa flourishes in hospital environments, and is a particular problem in this environment since it is the second most common infection in hospitalized patients. Perhaps this is because P. aeruginosa is one of the most active protein secreting bacteria. Here we summarize this wide range of secretion machineries, detail the numerous protein substrates which they export, and relate this to the pathogenesis of two of the sequenced clinical strains (PAO1 and PA14). We hope that this will prove a useful resource complementing previous comparisons between P. aeruginosa and the saprophytic plant symbiont P. fluorescens or other Pseudomonas species including non pathogenic P. putida read more ...