Zoë E. V. Worthington and Nicholas H. Carbonetti
from: Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis (Edited by: Karl Wooldridge). Caister Academic Press, U.K. (2009)
Bordetella pertussis is a Gram-negative bacterial pathogen that infects the human respiratory tract, causing the disease pertussis or whooping cough. B. pertussis produces a number of secreted virulence factors whose expression is coordinately regulated in response to environmental signals by the Bvg regulatory system. These virulence factors are secreted by a variety of different export pathways, including Type I, III, IV and V secretion systems. They are either cell-associated or released from the cell, and together they contribute to the pathogenic mechanisms employed by the bacteria to establish infection and cause disease. In this chapter, we discuss several of the better-characterized secreted virulence factors of B. pertussis with regard to their structure, secretion and role in pathogenesis read more ...