Protein Secretion and Pathogenesis in Neisseria meningitidis
David P. Turner, Karl G. Wooldridge and Dlawer A. A. Ala'Aldeen
from: Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis (Edited by: Karl Wooldridge). Caister Academic Press, U.K. (2009)
Neisseria meningitidis is the agent of meningococcal meningitis and septicaemia: two devastating human diseases. It is becoming apparent that secreted proteins are likely to play important roles in meningococcal disease and, furthermore, meningococcal secreted proteins may constitute attractive components of vaccines or targets of therapeutic intervention. The meningococcus has been shown to secrete a large number of proteins, some of which are capable of modulating host cell gene expression. Of the major protein secretion pathways identified N. meningitidis has been shown to secrete proteins via the Type I, autotransporter and two-component secretion pathways. Apart from genes encoding the Type IV pilus, the available meningococcal genomes do not appear to contain genes with homology to those encoding Type II, Type III or Type IV secretion systems, nor the recently described Type VI pathway read more ...