Protein Secretion and Pathogenesis in Campylobacter jejuni
Neil J. Oldfield and Karl G. Wooldridge
from: Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis (Edited by: Karl Wooldridge). Caister Academic Press, U.K. (2009)
Campylobacter jejuni is an important cause of human food-borne gastroenteritis that frequently colonizes poultry and contaminates their products. The high incidence of clinical disease associated with this bacterium, its low infective dose in humans and its potentially serious sequelae confirm its importance as a major public health hazard. Despite the medical and economic importance of C. jejuni infection, fundamental aspects of the patho-physiology of colonization and infection remain poorly understood. Here, we present an overview of protein secretion in C. jejuni and discuss the contribution of protein secretion systems to the pathogenesis and lifestyle of this bacterium. Both Sec dependent and TAT secretion systems are present. Of the protein secretion pathways that are widely disseminated among Gram-negative bacteria, only the type V (autotransporter) and a plasmid-encoded type IV-secretion system have been reported in C. jejuni. A type II-like system involved in natural competence, a functional flagella export apparatus and an uncharacterized system mediating cytolethal distending toxin secretion are also discussed read more ...