Secreted and Exported Proteins Important to Mycobacterium tuberculosis Pathogenesis
Jessica R. McCann, Sherry Kurtz, and Miriam Braunstein
from: Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis (Edited by: Karl Wooldridge). Caister Academic Press, U.K. (2009)
As with other bacterial pathogens, surface and secreted proteins of Mycobacterium tuberculosis are important to virulence. Many of these M. tuberculosis proteins are now known and significant progress is being made in identifying the systems responsible for their proper localization. There is also an increasing list of extracytoplasmic proteins proven to have a function in the virulence of M. tuberculosis. In this Chapter, we review the current understanding of the protein transport systems of M. tuberculosis and discuss some of the better characterized exported virulence factors of this important human pathogen read more ...