Caister Academic Press

Type V Secretion

Anthony Scott-Tucker and Ian R. Henderson
from: Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis (Edited by: Karl Wooldridge). Caister Academic Press, U.K. (2009)


The Type V secretion system was first described twenty years ago. During the intervening years much work has be done to elucidate functional aspects of members of this family and their mechanisms of biogenesis. What was once considered to be a quirky one-off system, with the discovery of the IgA1 protease secretion system of Neisseria gonorrhoeae, has been revealed as the largest family of secreted proteins amongst the Gram-negative bacteria. Here we review the current state of knowledge in the biogenesis of the T5SS, examining the steps involved in export across the inner membrane, transit through the periplasm, secretion across the outer membrane and folding of the secreted moiety on the cell surface read more ...
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