Caister Academic Press

The Organisation of Transcription and Translation

Peter Lewis and Xiao Yang
from: Bacillus: Cellular and Molecular Biology (Third edition) (Edited by: Peter L. Graumann). Caister Academic Press, U.K. (2017) Pages: 127-154.


The traditional view of transcription and translation within the cell was that of a very closely coupled process where translating ribosomes assembled on the nascent transcript as it was produced by transcribing RNA polymerase. Whilst this close physical coupling is undoubtedly important, it seems clear now that a number of other events are significant with respect to the physical organization of these two processes within the cell. Transcription is crudely segregated into two regions within the nucleoid where either stable (r- and t-) RNA, or mRNA transcription predominate. Translation by polysomes is enriched at cell poles, whereas the assembly of initiation complexes, and some transcriptionally linked ribosomes may occur throughout the nucleoid read more ...
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