RNA-mediated Regulation in Bacillus subtilis
Wade C. Winkler
from: Bacillus: Cellular and Molecular Biology (Second edition) (Edited by: Peter Graumann). Caister Academic Press, U.K. (2012)
Abstract
Bacterial genetic regulation is generally assumed to occur at the level of transcription initiation through the use of transcription factors. Regulatory mechanisms that take place post-transcription initiation are sometimes treated as anomalies - as exceptions to the rule. However, the actual degree of usage for post-initiation regulatory strategies in bacteria still remains to be fully determined. As evidence to this fact, recent research has significantly expanded the general understanding of post-initiation regulation in Bacillus subtilis and other bacteria. Regulatory RNAs are now predicted to control expression of numerous fundamental biochemical pathways that together constitute greater than 4% of the B. subtilis genome. Therefore, post-initiation regulation is a vital layer of bacterial genetic circuitry that still remains to be fully revealed read more ...
