Ins and Outs of the Bacillus subtilis Membrane Proteome
Jan Maarten van Dijl, Girbe Buist, Mark J.J.B. Sibbald, Jessica C. Zweers, Jean-Yves F. Dubois and Harold Tjalsma
from: Bacillus: Cellular and Molecular Biology (Edited by: Peter Graumann). Caister Academic Press, U.K. (2007)
Bacterial homeostasis is largely determined by a phospholipid bilayer that encloses the cytoplasm. The proteins residing in this cytoplasmic membrane are responsible for communication between the cytoplasm and extracytoplasmic cell compartments or the extracellular milieu of the cell. This chapter deals with the cytoplasmic membrane proteome of Bacillus subtilis. Specifically, we address current views on the role of membrane proteins in homeostasis, their membrane targeting and retention signals, machinery for membrane insertion, localization of membrane proteins, membrane protein degradation and, finally, the identified and predicted composition of the B. subtilis membrane proteome. Known mechanisms and current knowledge gaps are discussed in order to give a comprehensive overview of the in's and out's of the B. subtilis membrane proteome read more ...