Caister Academic Press

RNA-Mediated Regulation in Bacillus subtilis

Wade C. Winkler
from: Bacillus: Cellular and Molecular Biology (Edited by: Peter Graumann). Caister Academic Press, U.K. (2007)


In this chapter I will focus on regulatory mechanisms in Bacillus subtilis that are mediated through noncoding RNAs. Traditionally, bacterial genetic regulation is assumed to occur at the level of transcription initiation through the use of transcription factors. Regulatory mechanisms that take place post-transcription initiation are treated as anomalies - as exceptions to the rule. Although it is likely that regulation of transcription initiation by global factors will constitute the majority of overall bacterial regulation, the actual degree to which posttranscriptional regulation occurs is still unknown. As testament to this fact, the past several years have led to a rapid expansion in the understanding of posttranscriptional regulation in B. subtilis and other bacteria. Regulatory RNAs are now predicted to control expression of numerous fundamental biochemical pathways that together constitute greater than 4% of the B. subtilis genome. Therefore, regulation at the posttranscriptional level is a vital layer of bacterial genetic circuitry that still remains to be fully revealed read more ...
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