DNA Replication in Archaea
Brian R. Berquist and Shiladitya DasSarma
from: Archaea: New Models for Prokaryotic Biology (Edited by: Paul Blum). Caister Academic Press, U.K. (2008)
Abstract
Much initial study of archaeal DNA replication came as a direct result of complete genome sequencing, as the difficulty of culturing most archaea and their limited capability for genetic and biochemical manipulation in the laboratory had restricted the scope of studies. Here, we review bioinformatic, biochemical, and genetic work on identification of archaeal chromosomal DNA replication origins and the protein factors required for both DNA replication initiation and elongation. We highlight work done in both divisions of cultured archaea: the euryarchaea and the crenarchaea and attempt to provide unifying themes from analyses in diverse archaeal organisms read more ...
