Host Metabolism and its Contribution in Flavivirus Biogenesis
Rushika Perera and Richard J. Kuhn
from: Arboviruses: Molecular Biology, Evolution and Control (Edited by: Nikos Vasilakis and Duane J. Gubler). Caister Academic Press, U.K. (2016) Pages: 45-60.
Intracellular communication is key to cellular homeostasis. During infection of their hosts, viruses require a subversion of normal cellular communication pathways such that attention is focused towards efficient viral replication and virion biogenesis. Thus, the cellular environment is converted to a viral replication factory. Many viruses achieve this by significantly rearranging the intracellular membrane environment to form 'viral cobwebs' that extend throughout the cytoplasm. These cobwebs increase membrane contact sites within the cell and enhance cellular communication through signaling and transport of raw materials required for viral replication. Any form of intracellular conversion is directly linked to the metabolic pathways that drive cellular homeostasis. This chapter will therefore focus on the specific cellular metabolic pathways that are hijacked by viruses to achieve the formation of these viral replication factories. Specifically, we discuss how flaviviruses achieve an optimal cellular environment for replication and how these mechanisms seem conserved across species barriers as they replicate in both the human host and mosquito vector read more ...