Exploring New Insights into Fungal Biology as Novel Antifungal Drug Targets
Rebecca A. Hall and Robin C. May
from: Antifungals: From Genomics to Resistance and the Development of Novel Agents (Edited by: Alix T. Coste and Patrick Vandeputte). Caister Academic Press, U.K. (2015) Pages: 159-182.
Abstract
Although there are currently a number of good antifungal therapies available for the treatment of invasive fungal disease, the growing use of immune suppressive therapies and the ageing population has led to widespread use of antifungals. This overuse has lead to the development of antifungal resistance. Therefore, there is an urgent need for the identification of novel drug targets. This chapter highlights some of the recent discoveries in fungal biology including CO2 sensing, quorum sensing, cell wall biogenesis and intracellular proliferation, and we discuss the potential of these discoveries in the search for novel antifungal drug targets read more ...
