Drug Combinations as a Strategy to Potentiate Existing Antifungal Agents
Dominique Sanglard and Leah Cowen
from: Antifungals: From Genomics to Resistance and the Development of Novel Agents (Edited by: Alix T. Coste and Patrick Vandeputte). Caister Academic Press, U.K. (2015) Pages: 91-114.
Abstract
Antifungal treatments for combating fungal infections are usually administered as monotherapies. With the few antifungal agents available and the inevitable development of resistance in fungal pathogens, combination therapy may be a future alternative to augment the efficacy of existing agents by synergistic effects. This review gives an overview of attempts to identify effective in vitro or in vivo combination of known antifungals with each other and with other bioactive molecules. The search for synergistic drug combinations currently involves systematic screening of compounds libraries. The high number of possible combinations with their intensive experimental demand has stimulated in silico approaches predictive of drug synergisms. Here we summarize the achievements of these approaches that use mainly chemo-genomic methods in fungal model systems read more ...
