Antibiotics in the Pipeline
Hyunjun Park and Michael Thomas
from: Antibiotics: Current Innovations and Future Trends (Edited by: Sergio Sánchez and Arnold L. Demain). Caister Academic Press, U.K. (2015) Pages: 395-416.
The enormous success of using antibiotics to save lives is being challenged by the steady evolution of resistance to these antibiotics by the targeted bacteria. This resistance has led to predictions that we will soon be returning to the pre-antibiotic era whereby even the most minor infection has the potential to have severe consequences on the infected person. Fortunately, there has been a steady increase in the efforts to combat this rise in antibiotic resistance. This chapter discusses antibiotics for treating bacterial infections that were in the clinical pipeline at the beginning of 2014. While a list of the drugs that have recently been approved for clinical use or are in various phases of clinical trials is provided, a select few are highlighted in more detail to show how drug development itself is evolving to generate the next generation of antibiotics so the pre-antibiotic era stays in the past read more ...