Lantibiotics and Other Antibacterial Peptides
Margherita Sosio and Stefano Donadio
from: Antibiotics: Current Innovations and Future Trends (Edited by: Sergio Sánchez and Arnold L. Demain). Caister Academic Press, U.K. (2015) Pages: 321-330.
Lantibiotics and other ribosomally synthesized peptides have attracted increasing attention in the search for new chemical classes of antibacterial agents effective against multidrug-resistant pathogens. Several factors have probably contributed to this resurgent interest. Among them, the realization that many different classes of ribosomally synthesized peptides are produced by almost all taxa of bacteria; that lantibiotics, being ribosomally synthesized, are amenable to the generation of analogs by codon substitutions in the structural gene; and that, by binding to biosynthetic intermediates and not directly to enzymes, resistance in bacterial pathogens cannot be simply acquired by mutations in the target enzymes. In this chapter, we will review the chemistry, biosynthesis, occurrence and mechanism of action of lanthipeptides, with particular focus on lantibiotics. We will also present three lantibiotics that are currently under advanced preclinical or early clinical development, as well as some recently discovered compounds which represent improved variants of known lantibiotics read more ...