Antibiotics from Micro-organisms from Hot springs/Geysers
Girish B. Mahajan
from: Antibiotics: Current Innovations and Future Trends (Edited by: Sergio Sánchez and Arnold L. Demain). Caister Academic Press, U.K. (2015) Pages: 205-212.
Nature has provided mankind with abundant resources in the form of bioactive compounds which have been isolated from microbial resources. Novel natural products can have many innumerable potential uses, especially in the area of new drug discovery. Extensive research in this field has reported several terrestrial mesophilic sites. The marine environment has recently evinced more interest, and several thousands of novel bioactive compounds have been identified from various marine microorganisms. The constant need for new leads from the healthcare sector has sparked off a relentless quest for novel compounds. A difference in the habitat of the microorganisms yields different types of microorganisms, thus resulting in some variation in the types of compounds obtained from them. Physically and chemically extreme ecological units on the globe harbor special groups of microbes which are genetically well acclimatized to the stress conditions, and their adaptive ability makes them unique producers of different classes of compounds. Hot springs or geysers are such ecological niches, which have been studied mainly from their biodiversity point of view. There have been occasional reports of their harboring a huge cache of bioactive compounds from the drug discovery perspectives. In this article, we have tried to review present some such ecological niches read more ...