Tackling Antibiotic Resistance
Jaroslav Spizek and Vladimir Havlicek
from: Antibiotics: Current Innovations and Future Trends (Edited by: Sergio Sánchez and Arnold L. Demain). Caister Academic Press, U.K. (2015) Pages: 83-94.
Resistance to antibiotics and other antimicrobial compounds permanently increases and it appears that the struggle against antibiotic resistance is a war we can never win. The strength of the immense numbers of microorganisms appears to overpower our drugs. However, there are hopes and chances to at least improve the situation. In the present review we want to discuss certain steps to be used to tackle antibiotic resistance including: 1. Preparation of new vaccines against resistant bacterial strains, 2. Search for new antibiotics in both traditional and non-traditional sources 3. Search for genes specifying biosynthesis of antibiotics, 4. Use of forgotten natural compounds and their transformation, and 5. Search for new antibiotic targets. We want to devote a special attention to the search for new compounds that would inhibit the currently antibiotic resistant pathogenic bacteria read more ...