Caister Academic Press

Interactions Between HSV-1 and the DNA Damage Response

Matthew D. Weitzman and Sandra K. Weller
from: Alphaherpesviruses: Molecular Virology (Edited by: Sandra K. Weller). Caister Academic Press, U.K. (2011)


The cellular DNA damage machinery responds to virus infection and the foreign genomes that accumulate in the nuclei of infected cells. Many DNA viruses have been shown to manipulate the cellular DNA damage response pathways in order to create environments conducive to their own replication. Some cellular factors are activated during infection while others are inactivated. In this chapter we will focus on the complex cellular responses triggered by infection with HSV-1 and the consequences of its manipulation by viral factors read more ...
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