Mechanisms of Subversion of Type I Interferon Responses by Alpha Herpesviruses
Paul T. Sobol and Karen L. Mossman
from: Alphaherpesviruses: Molecular Virology (Edited by: Sandra K. Weller). Caister Academic Press, U.K. (2011)
Key to the innate immune response to alpha herpesvirus infection is the expression and secretion of type I interferons (IFNs). This family of cytokines bolsters a host offensive to invading pathogens by inducing IFN stimulated genes (ISGs). Not surprisingly, the evolutionary pressure faced by alpha herpesviruses to adapt to the type I IFN response has shaped alpha herpesvirus evolution at the very interface of the virus-host interaction. The cumulative effects of type I IFN expression on alpha herpesvirus replication in vitro and dissemination in vivo are discussed in this chapter, along with mechanisms employed by these viruses to subvert the type I IFN response. Specifically, this chapter will summarize how alpha herpesviruses block type I IFN production, inhibit the effects of type I IFN signal transduction and suppress downstream IFN-dependent effector pathways with the aims of augmenting viral replication and dissemination read more ...