Apoptosis Modulation During Herpes Simplex Virus Replication
Christopher R. Cotter and John A. Blaho
from: Alphaherpesviruses: Molecular Virology (Edited by: Sandra K. Weller). Caister Academic Press, U.K. (2011)
Consequences of human herpes simplex virus (HSV) infection include the induction of apoptosis and the concomitant synthesis of proteins which act to prevent this process from killing the infected cell. Recent data has clarified our current understanding of the mechanisms of induction and prevention of apoptosis by HSV; which ultimately establishes a delicate balance of pro- and antiapoptotic modulating factors in infected cells. These findings emphasize the fact that modulation of apoptosis by HSV during infection is a multicomponent phenomenon involving a combination of viral and cellular factors. We review recent evidence showing how this important human pathogen modulates the fundamental cell death process read more ...