Nuclear Egress and Envelopment of HSV
Joel D. Baines
from: Alphaherpesviruses: Molecular Virology (Edited by: Sandra K. Weller). Caister Academic Press, U.K. (2011)
In a process unique in biology, all herpesviruses obtain their initial virion envelope by budding through the inner nuclear membrane. In the most prominent model of virion egress, the envelope of the perinuclear virion then fuses with the luminal surface of the outer nuclear membrane, releasing the de-enveloped capsid into the cytosol for subsequent budding events. The pUL31/pUL34 protein complex is a major player in the initial budding event, and mediates several relevant functions including disruption of the nuclear lamina, recruitment of other viral proteins to the inner nuclear membrane and perinuclear virion, and budding of the nucleocapsid through the inner nuclear membrane. This review focuses on pUL31, pUL34, and other proteins known or believed to be involved in the initial budding event and egress from the perinuclear space read more ...