Multiple Roles of Immediate-Early Protein ICP22 in HSV-1 Replication
Stephen A. Rice
from: Alphaherpesviruses: Molecular Virology (Edited by: Sandra K. Weller). Caister Academic Press, U.K. (2011)
ICP22 is the least characterized of the five herpes simplex virus type 1 (HSV-1) immediate-early (IE) proteins. However, accumulating evidence indicates that it carries out a number of interesting regulatory activities inside the infected cell. These include the enhancement of viral gene expression, the modification of RNA polymerase II (RNAP II), and the reorganization of host cell molecular chaperones into nuclear inclusion bodies. Recent studies of engineered HSV-1 mutants indicate that certain of ICP22's activities are genetically separable from each other. Thus, similar to several other of the IE proteins, ICP22 appears to be a multifunctional, multi-domain polypeptide. This chapter summarizes the current state of knowledge concerning ICP22 and its varied regulatory roles during the productive HSV-1 infection read more ...