Immunity to Herpes Simplex Virus: Present but Not Perfect
Christopher D. Pack and Barry T. Rouse
from: Alpha Herpesviruses: Molecular and Cellular Biology (Edited by: R. M. Sandri-Goldin). Caister Academic Press, U.K. (2006)
Herpes simplex virus types 1 and 2 both represent significant human pathogens that infect a majority of the population. They should be controllable by vaccines, but despite notable effort, satisfactory vaccines remain unavailable. One hopes that fundamental studies of both the virus and how it interacts with the host will uncover clues useful for the design of effective prophylactic and therapeutic vaccines. This review focuses on host responses to the virus revealed in both animal models and human patient studies read more ...